The Insulin Wars: Greed, Glory, and the Battle to Save Lives

In the summer of 1921, in a dim and dusty laboratory at the University of Toronto, a young surgeon with failing prospects and a second-year medical student began tying off the pancreatic ducts of dogs. What they were after was elusive—unseen, unnamed, and possibly imaginary. What they found would change the fate of millions. They … Read more

Intermittent Fasting and Health – What’s the Scientific Evidence?

Our human ancestors had different food habits than we do. They did not routinely eat two to three regularly spaced, large meals every day. Indeed, food was often scarce, and there may have been long periods between meals. Furthermore, through the ages, fasting has been practiced in many communities for cultural and religious purposes. As … Read more

19 Important Causes of Fatigue – Tiredness and Chronic Fatigue Explained

“Fatigue is here, in my body, in my legs and eyes. That is what gets you in the end. Faith is only a word, embroidered.” ― Margaret Atwood, The Handmaid’s Tale. Fatigue or tiredness is a common medical complaint that may seriously affect people’s quality of life. However, despite many possible underlying causes, a specific medical disorder is seldom … Read more

The CANTOS Trial – Is Targeting Inflammation the Solution to Heart Disease?

The recently published results of the long awaited CANTOS trial may forever change our approach to the prevention and treatment of coronary artery disease (1). Inescapably, there is now proof that targeting inflammation, in this case by a drug, significantly improves outcome for certain very high-risk patients. But, as so often in clinical research, things … Read more

From Low-Fat, High-Carb to Insulin Resistance, Fatty Liver, and Heart Disease

I recently gave a talk at a meeting with colleagues, most of them cardiologists and endocrinologists, where I, among other things, discussed the current status of diet-heart hypothesis and the possible relationship between our fear of dietary fats and the obesity epidemic. After the meeting, a senior colleague of mine, an old friend, and a … Read more

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