A recent paper published in the American Journal of Clinical Nutrition provides updated results from the Women’s Health Initiative (WHI) Dietary Modification Trial (1). One of the questions raised is whether there is still hope for a low-fat dietary approach for the prevention of heart disease. The primary aim of the WHI Dietary Modification Trial was to […]
From Low-Fat, High-Carb to Insulin Resistance, Fatty Liver, and Heart Disease
I recently gave a talk at a meeting with colleagues, most of them cardiologists and endocrinologists, where I, among other things, discussed the current status of diet-heart hypothesis and the possible relationship between our fear of dietary fats and the obesity epidemic. After the meeting, a senior colleague of mine, an old friend, and mentor […]
Low-Density Lipoprotein (LDL) in Atherosclerosis and Heart Disease
The death rate from coronary artery disease (CAD) has declined considerably over the last three decades, mostly because of better control of risk factors and advances in therapy. However, due to the aging of the population and better survival of those affected, the prevalence of the disease remains high. The current epidemic of obesity and type 2 diabetes will likely escalate the problem further. Atherosclerosis, […]
Less Heart Disease Despite More Diabetes; The Role of Diet
The diverging trends in heart disease and diabetes represent a public health paradox of immense importance. Obesity and type 2 diabetes are well-known risk factors for coronary heart disease. However, whereas the prevalence of obesity and type 2 diabetes is increasing, the death rate from coronary heart disease is declining. This interesting paradox was recently addressed in two […]
The Road to Diabetes and Heart Disease – The “Ticking Clock” Hypothesis
One of the key reasons we do not want to get diabetes is that we will be more likely to be hit by heart disease or stroke or even Alzheimer’s disease for that matter. It’s scientifically proven. Having diabetes is associated with an increased risk of getting these disorders. But, does diabetes cause heart diseases or stroke? Hmm, […]
Which Is Most Atherogenic, High-Fat Cheese, High-Fat Meat or Carbs?
Atherosclerosis is the most common underlying cause of cardiovascular disease (CVD. It is caused by a complex interplay between lipoproteins, white blood cells, the immune system and the normal elements of the arterial wall. Atherosclerosis can affect all arteries in the body but seems to have a strong affinity for the coronary arteries. The resulting […]
Triglycerides – An Overview of the Role of Triglycerides in Heart Disease
As we grow older, we become more and more likely to develop heart disease. Obviously, we don’t think about it much in our twenties and thirties unless we’ve seen a close family member or a friend being hit by a heart attack or stroke. But, ultimately, most of realize that we should care. Since cardiovascular disease is […]
Cholesterol and Heart Disease – A Quick Look Beyond
The word cholesterol is inherent to heart disease. Just like Paris is the capital of France and the Moon orbits the Earth, so cholesterol is associated with heart disease. And common knowledge extends further. Most people know that cholesterol is measured in blood and that there’s is supposed to be both good and bad cholesterol. Bad cholesterol may […]
Obesity – Why and How Did We Get So Fat?
The modern history of coronary heart disease is quite remarkable. Acute myocardial infarction (acute heart attack) appears to have been relatively uncommon until it emerged in the early 1920s. Then came the plague. In the 1950s coronary heart disease had become the most common cause of death in the industrialized world. The symptoms were often dramatic and […]
HDL Cholesterol – The “Good” Cholesterol Explained
High-density lipoprotein cholesterol (HDL cholesterol) is commonly measured to assess the risk of heart disease. If you’ve had a blood sample drawn for assessment of lipid panel you probably already know if your cholesterol level is acceptable or not. You might also recall something about good and bad cholesterol and the ratio between these two. Of course, […]
Dietary Fat, Carbohydrates and Metabolic Syndrome
Time makes us fat. It’s not a myth, it’s a biologic fact. When we get old we get fat. In December 1863, William Banting, an English undertaker who went to great lengths to treat his own obesity, wrote in his now famous Letter on Corpulence: … For I have been generally informed that corpulence is one of the natural results of […]
The Triglyceride/HDL Cholesterol Ratio
For years, measurements of blood cholesterol have been used to assess the risk of heart disease. We have been intensively educated about the role of LDL-cholesterol (LDL-C), commonly nicknamed the bad cholesterol and HDL-cholesterol (HDL-C), often called the good cholesterol. For many different reasons, lowering LDL-C has become a primary goal in cardiovascular prevention. There is substantial […]
The Modern-Day Heart Patient – From One Risk Profile to Another
Although the death rate from coronary heart disease (CHD) has declined rapidly during the last few decades, CHD remains the most common cause of death in most countries around the world. The reduction in death rate is partly due to fewer people being diagnosed with CHD and partly due to a better prognosis of those […]
A Recipe For a Best Selling Health Book. Review of Grain Brain
My dream is to write a book on health that will sell millions of copies. I’ll introduce a great new dietary solution. I already have a strategic plan. Firstly, I am going to select a target group. Obviously, it has to be a large group of people. I’m going to write exactly what my target audience […]
Grain Brain – Take It With a Grain of Salt
During the last couple of decades Alzheimer’s disease and other types of dementia have become increasingly common. Today it is estimated that about 34 million people suffer from Alzheimer’s disease worldwide and the number is increasing rapidly. It is expected that the number of individuals with Alzheimer’s disease will triple over the next forty years. Therefore, preventing or reducing […]