The Fate of the PURE Study – Fat and Carbohydrate Intake Revisited

Most experts agree that diet is an important modifiable risk factor for cardiovascular disease and many other chronic noncommunicable disorders. Hence, defining and implementing a healthy diet is a matter of great public health interest. However, although there is substantial agreement on many issues, such as the importance of fruits and vegetables, several matters are still … Read more

Can Low-Fat Be Salvaged? – Updated WHI Dietary Modification Trial Results

A recent paper published in the American Journal of Clinical Nutrition provides updated results from the Women’s Health Initiative (WHI) Dietary Modification Trial (1). One of the questions raised is whether there is still hope for a low-fat dietary approach for the prevention of heart disease. The primary aim of the WHI Dietary Modification Trial was to … Read more

Low-Density Lipoprotein (LDL) in Atherosclerosis and Heart Disease

The death rate from coronary artery disease (CAD) has declined considerably over the last three decades, mostly because of better control of risk factors and advances in therapy. However, due to the aging of the population and better survival of those affected, the prevalence of the disease remains high. The current epidemic of obesity and type 2 diabetes will likely escalate the problem further. Atherosclerosis, … Read more

Less Heart Disease Despite More Diabetes; The Role of Diet

The diverging trends in heart disease and diabetes represent a public health paradox of immense importance. Obesity and type 2 diabetes are well-known risk factors for coronary heart disease. However, whereas the prevalence of obesity and type 2 diabetes is increasing, the death rate from coronary heart disease is declining. This interesting paradox was recently addressed in two … Read more

Which Is Most Atherogenic, High-Fat Cheese, High-Fat Meat or Carbs?

Atherosclerosis is the most common underlying cause of cardiovascular disease (CVD. It is caused by a complex interplay between lipoproteins, white blood cells, the immune system and the normal elements of the arterial wall. Atherosclerosis can affect all arteries in the body but seems to have a strong affinity for the coronary arteries. The resulting … Read more

Cholesterol and Heart Disease – A Quick Look Beyond

The word cholesterol is inherent to heart disease. Just like Paris is the capital of France and the Moon orbits the Earth, so cholesterol is associated with heart disease. And common knowledge extends further. Most people know that cholesterol is measured in blood and that there’s is supposed to be both good and bad cholesterol. Bad cholesterol may … Read more

Obesity – How and Why Did We Get So Fat?

The modern history of coronary heart disease is quite remarkable. Acute myocardial infarction (acute heart attack) appears to have been relatively uncommon until it emerged in the early 1920s. Then came the plague. In the 1950s coronary heart disease had become the most common cause of death in the industrialized world. The symptoms were often dramatic and … Read more

HDL Cholesterol – The “Good” Cholesterol Explained

High-density lipoprotein cholesterol (HDL cholesterol) is commonly measured to assess the risk of heart disease. If you’ve had a blood sample drawn for assessment of lipid panel you probably already know if your cholesterol level is acceptable or not. You might also recall something about good and bad cholesterol and the ratio between these two. Of course, … Read more