LDL-Cholesterol – The “Bad” Cholesterol Explained

There are several reasons why we should be interested in the amount of cholesterol circulating in our bloodstream. However, to interpret our cholesterol numbers, we have to know certain things about cholesterol and its role in health and disease.   What Is Cholesterol? Cholesterol is classified as a sterol (a combination of steroid and alcohol) … Read more

19 Important Causes of Fatigue – Tiredness and Chronic Fatigue Explained

“Fatigue is here, in my body, in my legs and eyes. That is what gets you in the end. Faith is only a word, embroidered.” ― Margaret Atwood, The Handmaid’s Tale. Fatigue or tiredness is a common medical complaint that may seriously affect people’s quality of life. However, despite many possible underlying causes, a specific medical disorder is seldom … Read more

The CANTOS Trial – Is Targeting Inflammation the Solution to Heart Disease?

The recently published results of the long awaited CANTOS trial may forever change our approach to the prevention and treatment of coronary artery disease (1). Inescapably, there is now proof that targeting inflammation, in this case by a drug, significantly improves outcome for certain very high-risk patients. But, as so often in clinical research, things … Read more

Can Low-Fat Be Salvaged? – Updated WHI Dietary Modification Trial Results

A recent paper published in the American Journal of Clinical Nutrition provides updated results from the Women’s Health Initiative (WHI) Dietary Modification Trial (1). One of the questions raised is whether there is still hope for a low-fat dietary approach for the prevention of heart disease. The primary aim of the WHI Dietary Modification Trial was to … Read more

From Low-Fat, High-Carb to Insulin Resistance, Fatty Liver, and Heart Disease

I recently gave a talk at a meeting with colleagues, most of them cardiologists and endocrinologists, where I, among other things, discussed the current status of diet-heart hypothesis and the possible relationship between our fear of dietary fats and the obesity epidemic. After the meeting, a senior colleague of mine, an old friend, and a … Read more