GLAGOV – The Lipid Hypothesis Gains Ground

The results from the recent GLAGOV trial suggest that aggressive lowering of LDL-cholesterol with a PCSK9-inhibitor on top of statin therapy in patients with coronary artery disease may reduce atherosclerotic plaque burden. Although these results provide support for the lipid hypothesis and may have significant implications for the future of cardiovascular medicine, our eyes are still on safety and … Read more

Apolipoprotein E – ApoE Explained

Apolipoprotein E (ApoE) is one of the proteins the body uses to transport fats (lipids) in the bloodstream from one tissue or cell type to another. It is essential for healthy metabolism of cholesterol and triglycerides, two important types of fats the body has to deal with regularly. The relationship between ApoE and heart disease has been studied quite intensively in recent … Read more

High Carbohydrate Intake Worse than High Fat for Blood Lipids

Data presented at the World Heart Federation’s World Congress of Cardiology & Cardiovascular Health 2016 (WCC 2016) in Mexico City may radically change our perspective on how carbohydrates and different types of fats affect blood cholesterol and other lipid biomarkers. The presentation was based on data from the Prospective Urban Rural Epidemiological (PURE) study. The data have not been … Read more

Fructose Restriction – An Effective Lipid Intervention?

The association between lipid disorders and heart disease is well known. Medical checkups usually involve measurements of cholesterol and other lipid parameters, and most doctors advise their patients on how to improve their lipid pattern. Dietary interventions to lower the risk of heart disease commonly aim at reducing blood levels of cholesterol, LDL cholesterol in particular. This is … Read more

Do Lipid Biomarkers Like Cholesterol Predict Cancer Risk?

Lipid biomarkers are frequently used to assess the risk of heart disease.  A simple blood test provides information about LDL-cholesterol (LDL-C) (1), commonly nicknamed the bad cholesterol and HDL-cholesterol (HDL-C) (2), often called the good cholesterol. Triglycerides are usually measured as well (3). For many different reasons, lowering LDL-C has become a primary target for the prevention of heart disease. Evidence … Read more