The recently published results of the long awaited CANTOS trial may forever change our approach to the prevention and treatment of coronary artery disease (1). Inescapably, there is now proof that targeting inflammation, in this case by a drug, significantly improves outcome for certain very high-risk patients. But, as so often in clinical research, things […]
Obstructive Sleep Apnea (OSA) – An Overview
Obstructive sleep apnea (OSA) is a relatively common sleep disorder with several potentially serious consequences. It causes breathing to stop and then start again intermittently during sleep. The word apnea describes suspension of breathing.OSA may seriously affect quality of life and is strongly associated with the risk of diabetes, high blood pressure, liver disorders and […]
Polycystic Ovary Syndrome (PCOS) – From Symptoms to Diagnosis and Treatment
Polycystic ovary syndrome (PCOS) is a common disorder among women. It is characterized by menstrual irregularities, infertility, signs of androgen excess, and polycystic ovaries. It is often associated with obesity, insulin resistance, and lipid abnormalities. PCOS is the most common cause of infertility in women (1). PCOS was first described in 1934 by Irving F. Stein […]
Uric Acid, Hyperuricemia, and Gout
More than eight million people in the U.S., almost 4% of the population, are estimated to suffer from gout. The disease often causes severe pain and physical disability. Gout is associated with increased blood levels of uric acid, called hyperuricemia. Uric acid is a biochemical substance the body has to deal with through our lifetime. It is an end […]
VLDL – The Role of Triglyceride-Rich Lipoproteins and Remnant Cholesterol
Knowing the role of VLDL (very low-density lipoprotein) and chylomicrons is a key factor in understanding how lipids (fats) and lipoproteins are involved in atherosclerotic cardiovascular disease (ASCVD). In the current era of adiposity and metabolic disease, VLDL has gained a bigger role than before and may help explain many of the disorders associated with the obesity epidemic such […]
Adiposity, Adipokines, and Adiposopathy – Sick Fat Explained
By now, all of us should know that we are in the throes of an obesity epidemic. Worldwide, over 500 million people are believed to be affected (1). Obesity in children and adolescents is on the rise and so is type 2 diabetes. And, according to the media and the experts, this will have horrible consequences that ultimately will […]
Fructose Restriction – An Effective Lipid Intervention?
The association between lipid disorders and heart disease is well known. Medical checkups usually involve measurements of cholesterol and other lipid parameters, and most doctors advise their patients on how to improve their lipid pattern. Dietary interventions to lower the risk of heart disease commonly aim at reducing blood levels of cholesterol, LDL cholesterol in particular. This is […]
Fructose – The Role of Fructose in Metabolic Syndrome and Heart Disease
Mark already ignores me. I think it is because I am in bed and I am a ‘stationary’ object, because once or twice at home when he saw me up and on the way to the toilet he evinced great interest at once. I am absolutely determined to check myself in any tendency to be […]
Low-Carb Diet to Treat Non-Alcoholic Fatty Liver Disease – Does It Make Sense?
Approximately 30 percent of people in the United States have a disease that is characterized by abnormal deposits of fat in the liver. The disease is not contagious, and unlike many other disorders of the liver, it is not caused by overconsumption of alcohol. It is called non-alcoholic fatty liver disease (NAFLD) and has become the leading cause of chronic liver disease […]
Added Sugar – Why and How to Avoid It
When it comes to the science of nutrition, everyone seems to have an opinion. Consequently, there is huge disagreement, even among the experts. If we ask for advice, there are likely to be dozen different answers. So, in the era of information overflow, the general population, has become severely confused. Apart from having to choose […]
The Road to Diabetes and Heart Disease – The “Ticking Clock” Hypothesis
One of the key reasons we do not want to get diabetes is that we will be more likely to be hit by heart disease or stroke or even Alzheimer’s disease for that matter. It’s scientifically proven. Having diabetes is associated with an increased risk of getting these disorders. But, does diabetes cause heart diseases or stroke? Hmm, […]
HbA1c and Diabetes – Glycated Hemoglobin (A1c) Explained
Diabetes and its complications remain a major cause of early disease and death worldwide. The diagnosis of diabetes is to a large extent based on detecting elevated levels of sugar (glucose) in the blood. Hemoglobin A1c (HbA1c) is a laboratory measure frequently used for this purpose. The test is also useful to monitor treatment in patients with established […]
Nonalcoholic Fatty Liver Disease (NAFLD) – Fatty Liver Explained
Recently, non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease in the United States and other Western countries. The prevalence of the disorder is estimated to be as high as 30% in the general population (1). With obesity being a major risk factor and due to the aging of the population, the […]
Statins and Diabetes – Time to Let the Cat out of the Bag
Recently, concerns have been raised about the increased risk of diabetes associated with statin therapy. However, it has been pointed out that the risk of diabetes is low in absolute terms and when compared with the reduction in cardiovascular events achieved by treatment. In other words, the potential benefits to health are believed to outweigh potential […]
Metabolic Syndrome and Insulin Resistance
The metabolic syndrome is a constellation of risk factors, most usually associated with increased body weight, fat accumulation around the abdominal organs often termed central, or visceral obesity (1), and increased resistance to the effects of insulin. Other names that have been used to describe the metabolic syndrome are syndrome X, the insulin resistance syndrome, the deadly quartet (2) and […]