Apolipoprotein B (ApoB) and the Real Risk of Heart Disease

In cardiovascular medicine, some numbers are sacred. LDL-cholesterol (LDL-C) has long been the cornerstone of risk assessment and treatment targets. But what if we’ve been following the wrong number? This updated article revisits and expands on a piece I wrote in 2021 — enriched by new evidence, deeper clinical insights, and a clearer understanding of … Read more

The Ghost in the Guidelines: How the Fat Debate Shaped the Story of Heart Disease

Just days ago, something remarkable happened.
FDA Commissioner Marty Makary stood at a podium and said what would’ve once been unthinkable.
That dogma still lives large,” he declared, referring to America’s decades-long war on saturated fat. “You see remnants of it in the food guidelines that we are now revising.”
It wasn’t just a revision. It was a rebuke.
Makary didn’t mince words. He called the foundational science behind decades of dietary advice—especially…